Background: Peyronies disease (PD) is a physically and psychologically debilitating illness marked by a fibrous inelastic tunica albugenia scar that results in a visible penile scar and deformity.
Objective: In order to assess the efficacy of intralesional injection of platelet rich plasma to Mitomycin-C with Dexamesathone in the treatment of Peyronie's Disease, researchers conducted a study.
Patients and methods: This study was Prospective interventional randomized comparative trial carried out on adult's male Patients with Peyronie's disease who visited the Andrology outpatient clinic, Kasr El Aini Hospital, and Cairo University.
Only 50 patients with Peyronie's disease were included in the first screening of 75 patients who complained of PD. The study enrolled those who met the inclusion criteria.
Results: There was a statistically significant improvement in PDQ domains, and IIEF scores after treatment with no superiority of neither option. Additionnaly, degree of curvature and erectile dysfunction improved in both groups after treatment as well; but to a different extent.
Conclusion: Intralesional injection of PRP and Mitomycin-C plus Dexamesathone could improve Peyronie's Disease symptoms. Mitomycin-C plus Dexamesathone more effective than PRP Penile curvature and plaque size improvement, while PRP was more effective in improvement of erectile function.