Background: Delayed wound healing is a key factor in the development of chronic wound complications so we can utilize the wound healing promotion properties of platelet rich plasma in decreasing the incidence of these complications.

Patients and Methods: A total number of 50 patients with open wounds resulting after surgical debridement of various types of soft tissue infection were included in this study, two groups with 25 patients for each were divided randomly. Group A patients were treated with PRP while group B was the control group treated with ordinary dressing. The two groups were monitored every other day for the first week and then every week until complete wound healing was achieved for pain, wound dimensions over the first three weeks, infection, full recovery time and development of residual complications.

Results: A total number of 50 patients, with a mean age of 22.35 years of them 37 males and 13 females. There was statistically significant difference between the two groups in the mean of pain score. As regard wound dimensions after three weeks of treatment there was statistically significant difference with a mean of 2.5 cm in the group A and 4 cm in the group B. there was statistically significant difference in wound infection rate and full recovery time with 2% and mean 28 days in group A while 20% and mean 37 days in group B respectively.

Conclusion: PRP therapy seems to be safe and effective in enhancing wound healing and in prevention of chronic wound complications.