Background: Colorectal cancer (CRC) is cancer of the colon and rectum. It arises from the mucosa that lining the colon, rectum or both.
Aim of the work: Determination of the clinical, lifestyle, and socio-demographic risk factors of colorectal cancer in Egypt.
Patients and Methods: A hospital-based, case-control study design was performed. 160 cases with CRC and 300 healthy subjects were recruited in this study. An endoscopic, radiological and pathological methods and clinical examinations had been done for the collection of data.
Results: The most significant risk factors for medical and family were obesity, DM, bowel habit change, inflammatory bowel disease (IBD), precancerous colonic lesions, no NSAIDs use, no HRT use, cholecystectomy, and family history of CRC (ORs=2.12, 2.13, 1.97, 4.91, 5.46, 3.69, 6.3, 3.84, and 8.88; respectively).
Conclusion: The most important risk factors of CRC were obesity, DM, IBD, precancerous colonic lesions, and family history of CRC. Risk factors of CRC are commonly controllable.