Background: Pre-eclampsia is a heterogeneous disease influencing various systems of the body and commonly accompanied by morbidity and death. Early pre-eclampsia prognostication would decrease this accompanied morbidity and death as it will give the chance for common motherly and fetal surveillance and utilization of prophylactic operations.
Objective: To assess whether the use of maternal platelet indices combined with uterine artery Doppler during 1st trimester could enhance the prediction of later pre-eclampsia in primigravidae women.
Methods: This prospective study includes 30 pregnant women selected from Obstetrics and Gynecology department, Al-Azhar university hospitals. All the selected pregnant women were primigravidae in 1st trimester at the start of the study. The study was conducted from October 2020 to May 2021.
Results: The uterine artery Doppler indices in prognostication of Pre-eclampsia were: sensitivity 85.7%, specificity 91.3%, NPV 95.5%, and PPV 75% with an accuracy of 90%. The maternal platelets indices in prediction of Pre-eclampsia were: sensitivity 57.14%, specificity 91.3%, NPV 87.5%, and PPV 66.67% with an accuracy of 83.3%. The combined uterine artery Doppler and maternal platelets indices in prognostication of Pre-eclampsia were: sensitivity 85.7%, specificity 100%, NPV 95.8%, and PPV 100% with an accuracy of 96.7%.
Conclusion: In our study, we figured out that the maternal platelets indices in combination with the Doppler assessment of the uterine artery as reliable screening tests to enhance the prognostication of Pre-eclampsia in primigravidae at the 1st trimester.