Background: Magnetic Resonance Imaging (MRI) has many advantages in the investigation of Multiple Sclerosis (MS). It delivers precise measurements of disorder activity, simplifies accurate diagnosing, and help in the evaluation of novel treatments. The present work aim is to recognize the roles of MRI in in the characterizations of MS-connected brain and spinal cord involvement. Methods: 30-cases relapsing-remitting MS (RRMS) cases were involved. The number, volume, and distribution of brain MRI lesions have been assessed via T2-weighted (T2W) image. Cross-sectional full normalized brain volume (NBV), normalized deep gray matter volume (NDGMV), normalized white matter volume (NWMV), normalized cortical gray matter volume (NCGMV), and normalized thalamic volume (NTV) have been calculated. Results: MRI findings revealed that the mainstream of case's lesions were detected via T2W-imaging with a mean value of Number of lesions measured of 4.43±3.329, MRI accuracy to detect MS was 86.67% with sensitivity and specificity 88.9 and 66.7 correspondingly, Conclusion: MRI suggestion have a supporting function in what is eventually a clinical MS diagnosing, in the suitable medical condition, and at all times at the exclusion of substitute diagnosing. MRI has improved into the most significant tool for diagnosing and screening of MS. Its elevated sensitivity for the assessment of inflammation and neuro-degenerative procedures in the brain and spinal cord has made it the commonest employed way for the valuation of MS-cases, Key words: Magnetic resonance imaging, multiple sclerosis