Hyperemesis gravidarum is a condition that affects pregnant women (HG),serum levels of human chorionic gonadotropin (hCG) and estradiol are increased than in pregnant women who are not influenced.Objective:This study's major goal was to learn moreabout how elevated human chorionic gonadotropin levels and estradiol affect the intensity of hyper emesis gravidarum during the first trimester.Methods: At El Hussein University Hospital, our prospective study was conducted from May 2020 to Nov. 2020; duration of the study was 7 months. The key sign of severe Hyper Emesis Gravidarum was a lengthy stay in the hospital (HG).The term "extended hospital stay" describedas stay ≥4 days, as this cut-off value demarcates the top quartilef orhospitalization timein our study population. Results: There was a highly significant difference between cases with hospital stay< 4 days and cases with hospital stay ≥ 4 days as regard HCG, cases with longer stay have higher median HCG (300637) compared to cases with