Background: Pregnant experiences physiological changes in maternal lipid metabolism to support fetal development. In some cases a misadaptation occurs and exceeds the physiological range and dyslipidemia is recognized, some pregnancies pacing without alterations and in pregnancies pacing without compilations.

Objective: determine the relation between maternal lipid profile and pregnancy complications and perinatal.

Patients and Methods: A Prospective study conducted on 164 pregnant throughout the period May 2018 – October 2019. Methodology: Pregnant were assessed clinically, obstetrically & tested for lipid profile during 2nd & 3rd-trimester, for detecting any maternal or neonatal complications.

Results: 28 pregnant developed maternal complications [GHTN (3.66%), Pre-eclampsia (2.44%), GDM (3.05%), IHCP (1.83%), PTL (4.27%), PTB (3.05%) & ROM (4.78 %)]. Lipid profile parameters in complicated cases during 2nd/3rd trimester for TC, TG, LDL & HDL were 189.3±4.8/243.2±4.8 mg/dl, 271.0±8.4/251.2±8. 4 mg/dl, 110. 8±5.6/114.2±5.6 mg/dl) & 60.4±1.8/61.2±1.9 mg/dl). We observed every mg/dl elevation in maternal third-trimester TG concentration was associated with an increased risk of GDM (P= 0.009), GHTN (P= 0.00), preeclampsia (P= 0.001) and IHCP (P= 0.005). Every mg/dl increase in 3rd trimester TG concentration was associated with an increased risk for SGA, LGA & macrosomia. In contrary, every mg/dl increase in 3rd trimester TG concentration was associated with decreased risk for Low Apgar score.

Conclusion: maternal dyslipidemia is a risk factor & associated with developing & occurrence on maternal complication during pregnancy & effect neonatal outcome. Testing lipid profile during second & third trimesters can early predict certain disorders associated with pregnancy.