Since the Corona pandemic began a year ago, the world has held its breath. Everyone is looking for hope to end this epidemic that has killed hundreds of thousands and sickened millions around the world. This will only be achieved by acquiring community immunity by either infecting the largest number of the planet's population or producing an effective and safe vaccine.1 In the past few days, companies of Vaccine developers and governments around the world announced, in media statements, that the vaccine production experiments have been successful and that its effectiveness has exceeded 90%. So governmental institutions, led by the US Food and Drug Administration, have provided an emergency permit to administer the vaccine to humans. Here the question arises, how safe are those vaccines? especially since clinical trials may haven't been fulfilled as required because of the emergency situation. These vaccines will be given to billions of people with different genetic predispositions and different age groups and disease states, which means a differentiated immune response.2 Perhaps this immune response could be dangerous or unexpected. Then what are the immunological results that may appear after a year or two or after many years. Also, data deficiency burdens the regulatory process by the FDA and other governmental health authorities. This article searches the scientific answers based on published articles in Scopus and Clarivate data bases. Scientific Clinical Evidence for long term Safety of Newly Evolved COVID_19 Vaccines.