Introduction The most important event of radiation treatment (RT) is to dependably expand the positions to the target volume while limiting the side effects to the normal tissues. Thusly, day by day treatment arrangement is considered as a basic necessity in RT for an exact positions and setup accuracy for treatment. Materials and Patients this is phase 2 study aiming to evaluate setup uncertainty related to pelvic cancer radiotherapy in the Clinical Oncology and Nuclear Medicine Department, at Al Hussein hospital, Al-Azhar University and to estimate how large planning target volume margins are needed in the Pelvic. Results and Discussion the mean variation for action level for plan is 3.3 mm (1SD) for pelvic. The greatness of precise and irregular mistakes for pelvic in our investigation are comparable or not exactly different examinations. To contrast the outcomes and other distributed investigation, we have considered PTV (90, 95,) margin. In our investigation, the determined CTV-PTV edge for pelvis patient c in the vertical, longitudinal and horizontal bearings were 4.12 mm, 4.62 mm and 3.23 mm, individually. Conclusion The consequences of this examination are distinctive to the discoveries of current work. In the present work, we have changed the isocenter in the fourth portion, which brought about decrease of the efficient mistakes. Another distinction can be ascribed to the recurrence of online confirmation.