Background and Aims: Fecal Microbiota Transplantation (FMT) is a novel form of therapeutic microbial manipulation aims to restore the intestinal microbiota in diseased individuals by transferring intestinal microbiota of healthy donors. We aimed to establish the efficacy of, multi donor, fecal microbiota transplantation in active ulcerative colitis(UC) in Egyptian patients.
Subjects and Methods: known UC patients (n-50) were divided in two groups, Group one included 25 patients who treated with medical treatment alone and then follow up was done for 24 weeks. Group two included 25 patients who treated with medical treatment and underwent FMT via complete colonoscopy every three weeks until the 9th week and then follow up was done for the24th week by clinical picture, laboratory investigation ,complete colonoscopy at 0, 3, 6, 9, 18 and 24 weeks of study.
Results: We found statistically significant difference between both groups as regard clinical remission(reduction in mayo score≤2) was achieved in 18(72%)patients of group II compared to only 5(20%) patients of group I achieved clinical remission p value(0.001) and statistically significant difference between both groups as reduction in leucocytic count which is more prominent in group II(5.8) rather than group I(6.2) p value (0.008) and statistically significant difference between both groups as improvement in anemia which is better in group II(12.4) than group I(11.9) p value (0.027).
Conclusion: FMT appears to be effective for induction of remission in UC, Further studies are needed to explore its feasibility, efficacy and safety as a maintenance agent.