Nature is a continuous source of architectural inspiration. It is important to use the advantage of the biological systems to solve many architectural problems. The research problem focused on the need for a clear methodology to apply the biological sciences in architecture. Biodigital architecture offers new strategies for both ontological and epistemological design process, which will increase the utilization of biological field in architecture. The aim of the present study is to reveal the effect of the biodigital architecture strategy on the design process by conducting a theoretical study of its biological and numerical aspects and adding new concepts and methodology to the design process. As the ontology integrates with epistemology in philosophy, the anthropological and epistemological aspects of the design process of the biodigital architecture and the monitoring of the biodigital architecture strategy in the design process; and with the selection of seven architectural projects that implemented the biodigital architecture strategy.   The seven case studies has diversified its architectural purposes from residential, medical, commercial and even multi-purpose buildings to monitor the diversity of purpose of the design process. The diversity of project sizes from pavilion, rooms, houses, communities, towers, The design process, in addition to taking into account the time period between these projects and their selection between 2007 and 2017, the period represented for the past 10 years, with a view to monitoring the technical development used in the design process; and then conducting an analytical study of the longer side And the epistemology of the design process of each of them according to the standard model resulting from the theoretical study.   The results of the study showed that the use of the biodigital architecture strategy, which bears in its natures the integration of the ontological side of biological architecture, the epistemological aspect of digital architecture and the addition of biodigital architecture to both design through nature in physical or digital form, For architectural reality leads to the benefit of the biological system in architectural applications and makes the design process extends from principles such as friendship with the environment and the simulation of nature to the construction through nature itself, Design extends from the simulation in the form of mass and architectural structure to the structural formation processes and biological stages of biological growth, as it extends from the simulated behavior on the level of material and functionality to the direct interaction with nature as part of it.