Beta
ManageSearchChatDiscover
277237

In Vivo Investigation of the Ameliorating Effect of Copper Albumin Complex on chondroitin sulfate in Monosodium iodoacetate -Induced Knee Osteoarthritis

Article

Last updated: 03 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

-

Abstract

Osteoarthritis (OA) is a condition that manifests as cartilage deterioration and subchondral bone sclerosis in the joint tissues. The weight-bearing joint is most severely impacted by OA. According to some research, consuming foods high in copper albumin complex (cu-albumin complex) can help with OA-related joint degeneration and pain relief. The current study's objective to determine how oral administration of the cu-albumin complex as an anti-inflammatory medication affected the development of rat knee osteoarthritis (KOA). Fifty adult albino rats were divided into three groups: negative control untreated (n= 10, no KOA induction); positive untreated control (n= 20, KOA induction); and treated group (n= 20, KOA induction with administration of cu-albumin complex). According to the severity of the clinical symptoms, treated and untreated arthritic groups were equally divided into mild and severe groups (n=10). Monosodium iodoacetate (MIA) was used as intra-articular injection for osteoarthritis induction. Rats were euthanized after a month of the beginning of the experiment, and the joints were examined histopathologically and immunohistochemically. It was indicated that the treatment was effective in reducing KOA severity and in improvement of chondroitin sulfate of the affected cartilages. In conclusion, the structure of the chondroitin sulfate in the knee joint cartilages of KOA-affected rats was modified by the cu-albumin complex.

DOI

10.21608/svu.2022.153878.1219

Keywords

Chondroitin sulfate, Copper albumen complex, Immunohistochemistry, Mankin scores, osteoarthritis

Authors

First Name

Doaa A.

Last Name

Elnakip

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

-

City

-

Orcid

-

First Name

Nashwa A.M.

Last Name

Mostafa

MiddleName

-

Affiliation

Department of histology and cell biology, Faculty of Medicine, Assiut University, Assiut

Email

-

City

-

Orcid

-

First Name

Asmaa

Last Name

Metwally

MiddleName

Abdelsalam

Affiliation

Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528

Email

asmaaabdelsalam104@yahoo.com

City

Aswan, Egypt

Orcid

0000000185658220

First Name

Reham I.

Last Name

El-Mahdy

MiddleName

-

Affiliation

Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University

Email

-

City

-

Orcid

-

First Name

Ahmed Y.

Last Name

Nassar

MiddleName

-

Affiliation

Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University

Email

-

City

-

Orcid

-

First Name

Obeid

Last Name

Shanab

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

shanab.bio@vet.svu.edu.eg

City

-

Orcid

0000-0003-1981-279X

First Name

Khaled

Last Name

Ghareeb

MiddleName

-

Affiliation

Department of Animal and poultry behavior and management, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

khaled.ghareeb@vet.svu.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdeen

MiddleName

-

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh

Email

-

City

-

Orcid

-

First Name

Zainab M.

Last Name

Maher

MiddleName

-

Affiliation

Department of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

-

City

-

Orcid

-

First Name

Mohamed A. A.

Last Name

Mahdy

MiddleName

-

Affiliation

Department of Anatomy and Embryology, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

-

City

-

Orcid

-

First Name

Aya Sh.

Last Name

Metwally

MiddleName

-

Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, Aswan University, Aswan 81528, Egypt.

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Salah

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

-

City

-

Orcid

-

Volume

5

Article Issue

4

Related Issue

36969

Issue Date

2022-12-01

Receive Date

2022-08-02

Publish Date

2022-12-01

Page Start

153

Page End

164

Print ISSN

2535-1826

Online ISSN

2535-1877

Article File

SVU_Volume 5_Issue 4_Pages 153-164.pdf

PDF . 352.6kB

Link

https://svu.journals.ekb.eg/article_277237.html

Detail API

https://svu.journals.ekb.eg/service?article_code=277237

Order

277,237

Type

Research article

Type Code

712

Publication Type

Journal

Publication Title

SVU-International Journal of Veterinary Sciences

Publication Link

https://svu.journals.ekb.eg/

MainTitle

In Vivo Investigation of the Ameliorating Effect of Copper Albumin Complex on chondroitin sulfate in Monosodium iodoacetate -Induced Knee Osteoarthritis

Details

Type

Article

Created At

22 Jan 2023