Diabetes mellitus (DM) is multifarious group of disorders distinguished with hyperglycemia. Streptozotocin (STZ) induced diabetes frequently occurs animal model in the medical researches. Hence, amelioration of hyperglycemia associated with diabetes is a cardinal target for therapeutics. Therefore, this work aimed to assesses the possible ameliorative characteristic of Aloe vera and Amaryl in STZ-induced diabetes. In this study, forty male Wistar rats within average weight 130±20 gm and age 6-7 weeks were used. The animals were evenly divided; 10 rats of each as follow. Group 1 served as control. Group 2 only received STZ. Group 3 received STZ + Aloe vera extract. Group 4 received STZ + Amaryl. Venous blood samples collected for biochemical assay using colorimetric methods. Besides this, specimens from pancreas were excised for the histological findings. Biochemically, STZ induced diabetic rats led to significant elevation in mean levels of blood glucose, total bilirubin and malondialdehyde (MDA) when compared with control. Contrary, activity of superoxide dismutase (SOD) was significantly decreased in STZ induced group in comparison with control. In contrast, the administrations of Aloe vera and amaryl to STZ diabetic rats showed an improvement in the mean values of the altered parameters. Histopathology, diabetic group revealed vacuolation of the pancreatic B-cells, besides inflammatory edema. Aloe vera and amaryl treated groups exhibited apparently normal pancreatic tissues. Depending on theses evidence, we could say that Aloe vera followed by amaryl could have contributed for an improvement of the pathophysiological alterations promoted by STZ induced diabetes.