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262407

Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Academic veterinary sciences (Anatomy, Histology, Physiology and Biochemistry).

Abstract

Osteoarthritis (OA) is a degenerative disorder involving the joint, including cartilage and synovial fluids. Recent studies have sought to find curative therapeutics to decrease the adverse effects of OA and relieve associated pain. Globally, knee osteoarthritis (KOA) is the most common type of arthritis. The present study aimed to evaluate the anti-inflammatory effect copper albumen complex (cu-albumin complex) for the treatment of mono-iodoacetate (MIA)-induced KOA in Albino rats. A total of 50 adult male albino rats were involved and divided as follows; 10 rats were kept normal as negative control; 20 arthritic rats were kept untreated (positive control), and 20 arthritic rats were treated with cu-albumin complex orally for a month. Treated and untreated arthritic rats were divided equally (10 rats each) into mild and severe groups according to the severity of signs. The intra-articular injection of MIA in the right knee joint was used for induction of osteoarthritis. Using Mankin grading score, the results demonstrated that the treated groups had a better histological appearance than the control positive group. Additionally with the exception of a few shrunken chondrocytes, the mildly treated group showed less degenerative alterations and appeared virtually normal. While the severe treated group showed increased cellularity with decreased degenerated chondrocytes. It concluded that balanced copper consumption has a positive impact on the prevention and treatment of KOA.

DOI

10.21608/svu.2022.136512.1196

Keywords

knee, osteoarthritis, MIA, copper, Proteoglycan

Authors

First Name

Asmaa Z.

Last Name

Shabaan

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

-

City

-

Orcid

-

First Name

Nashwa A.M.

Last Name

Mostafa

MiddleName

-

Affiliation

Department of histology and cell biology, Faculty of Medicine, Assiut University

Email

-

City

-

Orcid

-

First Name

Reham I.

Last Name

El-Mahdy

MiddleName

-

Affiliation

Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University

Email

-

City

-

Orcid

-

First Name

Ahmed Y.

Last Name

Nassar

MiddleName

-

Affiliation

Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University

Email

-

City

-

Orcid

-

First Name

Mohammed

Last Name

Salah

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

-

City

-

Orcid

-

First Name

Alsayed Abdelhamid

Last Name

Mohamed

MiddleName

-

Affiliation

Department of Anatomy, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

-

City

-

Orcid

-

First Name

AbdulRahman

Last Name

Saied

MiddleName

A

Affiliation

1 National Food Safety Authority (NFSA), Aswan Branch, Aswan 81528, Egypt. 2 Ministry of Tourism and Antiquities, Aswan Office, Aswan 81511, Egypt.

Email

saied_abdelrahman@yahoo.com

City

Aswan

Orcid

0000-0001-8616-58

First Name

Asmaa

Last Name

Metwally

MiddleName

Abdelsalam

Affiliation

Surgery department, Aswan University, Aswan

Email

asmaaabdelsalam104@yahoo.com

City

Aswan, Egypt

Orcid

0000000185658220

First Name

Mohammed

Last Name

Youssef

MiddleName

-

Affiliation

Department of Animal Physiology, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

mohamed.saleh@vet.svu.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Abdeen

MiddleName

-

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt

Email

-

City

-

Orcid

-

First Name

Harishkumar

Last Name

Madhyastha

MiddleName

-

Affiliation

Department of Cardiovascular Physiology, Faculty of medicine, University of Miyazaki, Miyazaki 8891692, Japan

Email

-

City

-

Orcid

-

First Name

Obeid

Last Name

Shanab

MiddleName

-

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523

Email

shanab.bio@vet.svu.edu.eg

City

-

Orcid

0000-0003-1981-279X

Volume

5

Article Issue

3

Related Issue

35342

Issue Date

2022-09-01

Receive Date

2022-05-10

Publish Date

2022-09-01

Page Start

112

Page End

125

Print ISSN

2535-1826

Online ISSN

2535-1877

Article File

SVU_Volume 5_Issue 3_Pages 112-125.pdf

PDF . 398.7kB

Link

https://svu.journals.ekb.eg/article_262407.html

Detail API

https://svu.journals.ekb.eg/service?article_code=262407

Order

10

Type

Research article

Type Code

712

Publication Type

Journal

Publication Title

SVU-International Journal of Veterinary Sciences

Publication Link

https://svu.journals.ekb.eg/

MainTitle

Ameliorative Effect of Copper Albumin Complex on Proteoglycan in Mono-iodoacetat Induced Osteoarthritis Rat Model

Details

Type

Article

Created At

22 Jan 2023