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246271

Molecular mechanism of Copper Albumin Complex on NDEA induced brain vascular damage via promoting VEGF expression.

Article

Last updated: 03 Jan 2025

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Subjects

-

Tags

Academic veterinary sciences (Anatomy, Histology, Physiology and Biochemistry).

Abstract

Nitrosodiethylamine (NDEA) is a potent oxidant induces neurodegeneration via (reactive oxgen species) ROS. Copper is an important metal essential for scavenging free radicals, development of central nervous system (CNS) and redox angiogenesis signaling. Vascular endothelial growth factor (VEGF) is well known as efficacious and long-term signal that stimulates angiogenesis, where its expression is copper dependent.We examined thecopper protective effect against brain vascular damage initiated by NDEA. NDEA induces brain vascular wall damage, necrosis with interstitial hemorrhage and diminishesVEGF expression. Histopathological examination showing a great improvement of brain tissue in copper treated mice with significant increase in VEGF expression.Higher levels of intracellular copper can stimulate angiogenesis and exhibited a significant protection against NDEA induced brain vascular damage,confirming its ability to enhanceantioxidant activity andangiogenesis initiation.Our report presents first evidence that inducible VEGF expression in brain is sensitive to copper; moreover Copper based therapeutics represents a novel approach to reducebrain vascular damage induced by NDEA generated ROS.

DOI

10.21608/svu.2022.133515.1192

Keywords

Nitrosamines, copper, VEGF, ROS, NDEA

Authors

First Name

laila

Last Name

taha

MiddleName

-

Affiliation

biochemistry,faculty of veterinary medicine,south valley univercity,qena,egypt

Email

lailamostafa_80@yahoo.com

City

Qena

Orcid

-

First Name

Zainab

Last Name

Maher

MiddleName

M

Affiliation

Department of Pathology and clinical pathology, Faculty of veterinary medicine, Qena university

Email

zainab.maher@vet.svu.edu.eg

City

Qena

Orcid

-

First Name

Ahmed

Last Name

Nassar

MiddleName

Y

Affiliation

3Department of Medical Biochemistry and Molecular biology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Email

aynassar41@yahoo.com

City

Assiut

Orcid

-

First Name

Mohamed

Last Name

Abdallah

MiddleName

s

Affiliation

Department of Biochemistry, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt.

Email

salah-bio@vet.svu.edu.eg

City

Qena

Orcid

-

First Name

hamdy

Last Name

embark

MiddleName

-

Affiliation

Department of Animal Physiology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt

Email

h.embark@vet.svu.edu.eg

City

qena

Orcid

-

First Name

Mohammed

Last Name

Youssef

MiddleName

-

Affiliation

Department of Animal Physiology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt

Email

mohammedyoussefsaleh@gmail.com

City

Qena

Orcid

-

First Name

Ahmed

Last Name

Abdeen

MiddleName

-

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.Center of Excellence for Screening of Environmental Contaminants (CESEC), Faculty of Veterinary Medicine, Benha University, Toukh, Egypt.

Email

ahmed.abdeen@fvtm.bu.edu.eg

City

benha

Orcid

-

First Name

Rofida F.

Last Name

Moftah

MiddleName

-

Affiliation

Food Science and Technology Department, Faculty of Agriculture, Assiut University, Assiut, Egypt.

Email

rofidamoftah@yahoo.com

City

assiut

Orcid

-

First Name

Harishkumar

Last Name

Madhyastha

MiddleName

-

Affiliation

Department of Cardiovascular Physiology, Faculty of medicine, University of Miyazaki, Miyazaki 8891692, Japan.

Email

hkumar@med.miyazaki-u.ac.jp

City

japan

Orcid

-

First Name

Obeid

Last Name

Shanab

MiddleName

-

Affiliation

Department of Biochemistry, faculty of veterinary medicine, South Valley University, Egypt.

Email

shanab.bio@vet.svu.edu.eg

City

-

Orcid

0000-0003-1981-279X

Volume

5

Article Issue

2

Related Issue

32709

Issue Date

2022-06-01

Receive Date

2022-04-15

Publish Date

2022-06-01

Page Start

68

Page End

76

Print ISSN

2535-1826

Online ISSN

2535-1877

Article File

SVU_Volume 5_Issue 2_Pages 68-76.pdf

PDF . 695.0kB

Link

https://svu.journals.ekb.eg/article_246271.html

Detail API

https://svu.journals.ekb.eg/service?article_code=246271

Order

7

Type

Research article

Type Code

712

Publication Type

Journal

Publication Title

SVU-International Journal of Veterinary Sciences

Publication Link

https://svu.journals.ekb.eg/

MainTitle

Molecular mechanism of Copper Albumin Complex on NDEA induced brain vascular damage via promoting VEGF expression.

Details

Type

Article

Created At

22 Jan 2023