Interestingly, coffee is accentuated as a widespread stimulant beverage. Rising concern inferred an approach between coffee imbibe and an array of public health conditions. The existing study was predicated to clarify the crucial influences of the prolonger term intake of coffee drinks. Forty adult male albino rats were divided into four groups of ten rats each. First group employed as control. However, 2nd, 3rd and 4th groups were orally exposed to ascending concentrations of Mocha (Cappucinno) at 0.72, 1.44 and 2.16 ml, respectively daily for 7 weeks. Blood samples were dragged for an assessment liver functions, level of carcinoembryonic antigen (CEA) and mean of total testosterone hormone (T.T.) using standard kits methods. Furthermore, liver biopsies were taken for the histological screening. From biochemical aspect, serum levels of aspartate aminotranferase (AST), alanine aminotranferase (ALT), and alkaline phosphatase (ALP) were significantly exceeded the mean levels in a comparison with control, besides level of T.T. was remarkably decreased as when compared with control. By cross sectional screening, liver was frankly distinguished by degenerative disorders with cytoplasmic vacuolation as well congested blood vessels. Based on these findings, it could be concluded that cappuccino declaredly implying a detrimental effect on the consumers was evidently boosted by the time and concentration.