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17931

Disposition Kinetics of Cefepime in Healthy and Experimentally Salmonella Typhimurium Infected Broiler Chicken

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Last updated: 03 Jan 2025

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Abstract

Cefepime is a broad-spectrum semi synthetic β-lactamase resistant fourth generation cephalosporin.  Looking to potential for clinical use, pharmacokinetics of cefepime following single intravenous and intramuscular (IM) dose (100mg/kg b. wt.) in healthy and experimentallySalmonella typhimuriuminfected broiler chickens were determined.Cefepime concentration in serumsamples was determined by reverse-phase high performance liquid chromatography with mobile phase.  The mobile phase was a mixture of 10mM phosphate buffer (pH 7): Methanol; 75:25 was always freshly prepared.  Flow rates were 1 ml/min.  UV detection was performed at 256 nm, injection volume was 20 µl. After a single intravenous injection, cefepime reached its maximum serum concentrations of 4.28 ± 0.37μg/mlin normalchickens, while in the  infected chickens, the maximum serum concentration was 2.62 ± 0.72 μg/ml. Cefepime was eliminated after intravenous injection with half-life (t1/2 β) of 4.608 ± 0.145 h in normal which significantly longer than 4.19 ± 0.158 h in infected chickens. The mean residence time (MRT) was 6.51 ± 0.189h in normal vs5.86±0.18 h in infected chickens.  After IMadministration the drug reached its maximum serum concentrations of 193.06 ± 2.27μg/ml at maximum time of 1.138 ± 0.012 h in normal, while in infected chickens the maximum serum concentrations was 132.93 ± 1.53μg/mlattained atmaximum timeof 1.265 ± 0.013 h. In conclusion a cefepime at dose of 100 mg/kg administered intravenously or IMat 24 h intervals may provide successful treatment of chicken infected with Salmonellatyphimurium

DOI

10.21608/svu.2018.17931

Keywords

Cefepime, Salmonella typhimurium, High performance liquid chromatography, broiler, chicken

Authors

First Name

Taha

Last Name

Atti

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Affiliation

Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City,

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Orcid

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First Name

Hanan

Last Name

Azoz

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Affiliation

Biochemistry, Toxicology and Feed Deficiency Department “Pharmacology Unit", Animal Health Research Institute, Dokki, Egypt.

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Orcid

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First Name

Mohamed

Last Name

Shamakh

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-

Affiliation

Biochemistry, Toxicology and Feed Deficiency Department “Pharmacology Unit", Animal Health Research Institute, Dokki, Egypt.

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Volume

1

Article Issue

1

Related Issue

3752

Issue Date

2018-06-01

Receive Date

2018-05-30

Publish Date

2018-06-01

Page Start

66

Page End

81

Print ISSN

2535-1826

Online ISSN

2535-1877

Article File

SVU_Volume 1_Issue 1_Pages 66-81.pdf

PDF . 732.1kB

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https://svu.journals.ekb.eg/article_17931.html

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https://svu.journals.ekb.eg/service?article_code=17931

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6

Type

Research article

Type Code

712

Publication Type

Journal

Publication Title

SVU-International Journal of Veterinary Sciences

Publication Link

https://svu.journals.ekb.eg/

MainTitle

Disposition Kinetics of Cefepime in Healthy and Experimentally Salmonella Typhimurium Infected Broiler Chicken

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Article

Created At

22 Jan 2023