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17929

Lavender foal syndrome in Egyptian Arabian horses: molecular and pathological studies

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Last updated: 03 Jan 2025

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Abstract

Lavender foal syndrome is one of fatal genetic coat color -associated disorders in Arabian horses caused by a recessive gene. Arabian horse harbor heterozygous genes represent a carrier case with normal criteria, while that harbor homozygous genes mostly will had a characteristic lavender coat color and represented an affected case that will die within few days. Egyptian Arabian horses are incriminated to harbor up to 10% of this syndrome recessive gene and hence of great economic important for Arabian horse's industry. In this study we trace the historical appearance of LFS in the records of one Arabian horses farm, apply PCR followed by sequence analysis for 8 suspected cases.   On the other side pathological investigation of early dead foal with lavender coat color was carried out.Our results detected the incriminated single base deletion at the molecular level by sequence analysis of hair samples in four out of the eight suspected horses. Histopathological investigation was carried out on liver, kidneys and different regions of the brain of dead foal with lavender coat color. Moreover, immuno-histochemistry technique was done to clarify the possible LFS pathogenesis.  Our result reflects the principle role of myosin Va as a cargo molecule in LFS pathogenesis in association with development of endoplasmic reticulum stress effect with end result of multi-systemic effects

DOI

10.21608/svu.2018.17929

Keywords

lavender, foal syndrome, Arabian horse, MyosinVa, Endoplasmic reticulum, Pathology

Authors

First Name

Naglaa

Last Name

Alkalamawy

MiddleName

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Affiliation

Animal Health Research Institute, Pathology Department, Dokki -Giza,

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First Name

Dawlat

Last Name

Amin

MiddleName

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Affiliation

Animal Health Research Institute, Pathology Department, Dokki -Giza,

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Orcid

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First Name

Ibrahim

Last Name

Alkalamawy

MiddleName

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Affiliation

Biotechnology Unit, VACSERA- Giza,

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Orcid

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First Name

Iman

Last Name

Abd Elaty

MiddleName

-

Affiliation

Veterinarian in practice

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Volume

1

Article Issue

1

Related Issue

3752

Issue Date

2018-06-01

Receive Date

2018-06-01

Publish Date

2018-06-01

Page Start

55

Page End

65

Print ISSN

2535-1826

Online ISSN

2535-1877

Article File

SVU_Volume 1_Issue 1_Pages 55-65.pdf

PDF . 746.1kB

Link

https://svu.journals.ekb.eg/article_17929.html

Detail API

https://svu.journals.ekb.eg/service?article_code=17929

Order

5

Type

Research article

Type Code

712

Publication Type

Journal

Publication Title

SVU-International Journal of Veterinary Sciences

Publication Link

https://svu.journals.ekb.eg/

MainTitle

Lavender foal syndrome in Egyptian Arabian horses: molecular and pathological studies

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Article

Created At

22 Jan 2023