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22162

Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation

Article

Last updated: 03 Jan 2025

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Tags

Clinical Veterinary Sciences

Abstract

Cholestatic liver diseases can be induced for many reasons including obstructions, e.g. by stones or tumors. An early consequence of obstructive cholestasis is the formation of bile infarcts, which refer to clusters of dead hepatocytes due to bile salt accumulation. Although these infarcts were described long time ago (in 1876 by Charcot and Gombault), the leading mechanism is still unclear. Some hypotheses suggested direct killing by accumulation of bile salts up to toxic levels. Others claim indirect cell death via immune cell infiltration and inflammatory cytokine release. However, the sequence of events leading to the formation bile infarcts are still unclear. In the recent issue of Hepatology, Ghallab and his colleagues have recorded in a time-resolved manner the key events leading to bile infarct formation and the subsequent systemic changes, using two-photon based intravital imaging. This mini-review highlights the results of this study and discuss the time-resolved events in acute and chronic cholestasis, as well as the link between biliary bile salts and hepatocyte death.

DOI

10.21608/svu.2018.22162

Authors

First Name

Reham

Last Name

Hassan

MiddleName

-

Affiliation

Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.

Email

hassan@ifado.de

City

-

Orcid

-

First Name

Abdel-latif

Last Name

Seddek

MiddleName

-

Affiliation

Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt

Email

abdellatief-shakir@vet.svu.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Ghallab

MiddleName

-

Affiliation

Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.

Email

ghallab@ifado.de

City

-

Orcid

-

Volume

1

Article Issue

2

Related Issue

3750

Issue Date

2018-12-01

Receive Date

2018-12-16

Publish Date

2018-12-01

Page Start

95

Page End

105

Print ISSN

2535-1826

Online ISSN

2535-1877

Article File

SVU_Volume 1_Issue 2_Pages 95-105.pdf

PDF . 1.8MB

Link

https://svu.journals.ekb.eg/article_22162.html

Detail API

https://svu.journals.ekb.eg/service?article_code=22162

Order

10

Type

Review Article

Type Code

705

Publication Type

Journal

Publication Title

SVU-International Journal of Veterinary Sciences

Publication Link

https://svu.journals.ekb.eg/

MainTitle

Pathophysiology of Cholestatic Liver Diseases: New Insights into the Mechanisms of Bile Infarct Formation

Details

Type

Article

Created At

22 Jan 2023