Background: Nonvalvular atrial fibrillation (NVAF) frequently coexists with coronary artery disease (CAD); as they share similar risk factors and pathophysiology. However, the relation between CHA2DS2VASc score and CAD in patients with NVAF is not studied well. The objective of this study is to evaluate the correlation between CHA2DS2VASc score and the coronary angiographic findings in NVAF patients. Methods: This is a prospective, randomized, single center study that included all patients with NVAF attended Sohag University Hospital Cath. Lab. for Coronary angiography from first of January 2018 till end of December 2021. Demographic data, risk factors of coronary artery disease, different presentations, echocardiographic and coronary angiographic findings were analyzed and assessed. Results: More than half (56.2%) of patients with NVAF has CAD. The majority of NVAF patients with normal coronary angiography were in score 2. 26 patients had single CAD >50%; stenosis with 4 in score 0, 8 in score 1, 7 in score 2, 5 in score 3 and 2 in score 4. One patient had 2VD and was in score 2. 10 patients had 3VD; 2 in score 0, 5 in score 1, 2 in score 2, and 1 in score 3. Conclusion: More than half (56.2%) of the patients with NVAF has CAD based on coronary angiography. Single vessel CAD >50% was the most frequent lesion observed , meanwhile there was no correlation between the severity of the disease and CHA2DS2VASC score in NVAF patients.