There were 727 million persons aged 65 years or over in the world in 2020. Over the next three decades, the global number of older persons is projected to more than double, reaching over 1.5 billion in 2050 The aim of this study was to assess burden and coping mechanism among care giver for old age with advanced illness. A descriptive design is utilized in this study. A Convenience sample of caregivers was used it composed of 100 of caregivers and their patients who match the criteria: primary caregivers who provide care for the patients for at least one year and accept to participate in the study. Two tools were utilized 1: Interviewing questionnaire composed of 3 parts,Socio-demographic data,medical history of the patients,coping strategies used by the care giver to reduce 2to assess burden of caregivers. The result the current study revealed (43%) of the studied caregivers reported high level of burden and stress, flowed (32%) reported medium level of burden and (25%) reported low level of burden. This study conducted that caregiver factors as Age, gender, educational level, income status, knowledge of the diseases, and coping., patient factors (Age, clinical symptom, and disability in daily life), and environment factors (Health services and its utilization, and social support.) are major factors that affected caregivers' burden. The present study recommended that Provide guideline as well as clinical training to assist caregivers of chronic disease patients at home This helps them deal with the burden of care and manage the stress associated with it.