Background: Ageing is unavoidable developmental facts that bring along several changes in the physical, psychological, hormonal, and social status. Most of these changes are expected to affect the quality of life of the elderly. Aim: evaluate the effect of the psycho-educational program for enhancing the quality of life for the elderly at a geriatric home. Methods: a quasi-experimental research design was performed on a convenient sample consisted of 20 elderlies at Elhlal Elahmer and Noor Wel Amal geriatric homes that are located in Beni-Suef governorate, Egypt. Tools: Data were collected using 1) Socio-demographic Questionnaire, 2) Facts on Aging Quiz 3) The Older People's Quality of Life Questionnaire. Results: The result of this study showed that there is a higher improvement in the level of knowledge post-program than preprogram from (15% to 90%) and in follow up from (15% to 70%) sufficient knowledge and there is a higher improvement in the level of quality of life post-program than preprogram from (30% to 85 %) and in follow up from (30% to 70%) higher quality of life. Also, there is a highly significant relationship between total quality of life and total knowledge (p < 0.01) in pre, post and follow up programs. Conclusions: Psycho-educational program is effective in enhancing the quality of life and improving knowledge related to aging changes of the elderly in a geriatric home. Recommendations: The study recommended that develop awareness programs for elderlies that include all physical, psychological, and social consequences related to aging and how to manage it.