The current study was performed through 2020 season on apple cv. Anna. The experiment was performed on fifty uniform trees, which were of the same size and vigor as possible and subjected to the same applied cultural practices in the field. The trees were sprayed three times; before flowering, during full bloom and one month later with the following treatments: control (water only), Ag NPs at 10, 12.5 and 15 mL/L, Zn NPs at 100, 200 and 300 ppm and Zn at 0.25, 0.5 and 1.00 g/L. The treatments were arranged in a randomized complete block design where each treatment was composed of five replicates (five trees). The obtained results showed that spraying Ag NPs at 12.5 and 15 mL/L, Zn NPs at 200 and 300 mL/L and Zn at 1.00 g/L on apple trees increased significantly total chlorophyll, fruit set percentages, and fruit yield. Besides, the same treatments increased also the fruit's physical and chemical characteristics compared to control and the other applied treatments.