The present study was carried out at  Exerimpental Farm of Faculty of Agriculture (Saba Basha), Abess Region, Alexandria, Egypt during the two seasons of 2018/2019 and 2019/2020 to alleviate the effect of salinity on  barley (Hordeum vulgare L. cv. Giza 123)by using organic manure, salinity remediator andselenium. This experiment was conducted in split- split plot system in three replications during the two seasons. The main plots were organic manure (Without application (control), 12 and 24 m³/ha), the subplot was an application of salinity remediator (control, Agrosol Tonic at the rate of 12 L/ha with the first irrigation, Agrosol Tonic at the rate of 12 L/ha with the second irrigation) and foliar application of selenium (Se) rates (spray water, 5 ppm and 10 ppm) was distributed in a sub-subplot in both seasons. The obtained results showed that increasing organic manure from 0 to 24 m³ recorded the highest mean values of yield, yield components and protein (%) in grain, increasing application of Agro-Sol Tonic with 2^nd irrigation increased yield, yield components and protein (%) in grain and increasing selenium (Se) concentration up to 10 ppm increased these characters of barley. Concerning the first-order interaction, the highest mean values of these traits achieved by “24 m³ /ha from sheep manure + Agro Sol Tonic application with the 2^nd irrigation"; “24 m³ /ha from sheep manure + 10 ppm selenium concentration"; “Agro Sol Tonic application with the 2^nd irrigation + 10 ppm selenium concentration", while the lowest ones recorded with the control treatments (untreated) in the two seasons. Respecting to the second interaction order, the highest mean values of these traits achieved by 24 m³ /ha from sheep manure + Agro Sol Tonic application with the 2^nd irrigation + 10 ppm selenium concentration under salinity condition, while the lowest ones recorded with the control treatments (untreated)  under study conditions at Abess, Alexandria Governorate, Egypt.