To study the response of maize hybrids to organic manure and micronutrients NPs application. In this regard, two field experiments were conducted at the Experimental Farm, Faculty of Agriculture (Saba Basha), Alexandria University during 2018 and 2019 seasons at factorial experiments (two factors) in a split-plot system in three replicates. Where, the main plots allocated by farmyard manure rates (0, 10, 20 m³), while, the sub-main plots assigned with nano- practices of micronutrients (NPs) (spray water (control), nano- Fe, nano-Zn, nano- Mn, nano- Fe + Mn, nano-Fe + Zn and Fe + Zn + Mn) in both seasons. The results revealed that ear length (cm), number of rows/ear, number of grains/row, number of grains/ear, 100-grains weight (g), grain yield (t/fed), straw yield, biological yield (t/fed), harvest index (%) and grain protein content (%) of maize hybrid were, significantly, affected by organic manure and micronutrients NPs application, where soil application of sheep manure at the rate of 20 m³/fed with foliar application of combination between nano- Fe + nano- Zn + nano- Mn increased yield and its components of maize hybrid ‘TWC1100' under the conditions of Alexandria, Egypt.