Two field experiments were carried out at the Experimental Farm, Faculty of Agriculture (Saba Basha), Alexandria University, Egypt during 2017 and 2018 seasons, to study the effect of mineral, nano- fertilization, in addition to different weed control on growth and yield of sorghum. Split plot design with three replicates was used, where the main plots occupied by weed control treatments(hand hoeing one time before the first irrigation, hand hoeing twice the first one was before the first irrigation and the second one was before the second irrigation, Heraty sowing method, herbicide treatment before planting and herbicide treatment before planting + one hand hoeing), meanwhile, the combination between NPK mineral and NPK nanoparticles fertilizers (100% mineral NPK (240:60:60 kg/ha), 100% nano NPK (5 L/ha) and 50 % mineral NPK + 50 % nano NPK) were distributed at random within the subplots. Each subplot consisted of 5 ridges 3.50 m in length and 60 cm in the width and the plot area was 10.5 m². The results revealed that, the yield and its components of the sorghum hybrid (Horas) were affected by weed control methods, mineral NPK, Nano NPK and their interaction. The highest value of yield characters of sorghum was achieved when applying hand hoeing one time with herbicide with fertilizing by 50% NPK mineral + 50% NPK NPs fertilization, also these treatments reducing the effect of weeds under Alexandria conditions.