The present study was carried out during the period from October (2021) to April (2022). Blood samples were collected Among 25 covid-19 with HBV (17 male and 6 female), the percentage of males from the samples was 73.9%, with a mean age of 52 years. Ages range 20-79 years with covid-19 and viral hepatitis at Baghdad teaching hospital-Gastroenterology and liver hospital (in Baghdad) and Tikrit hospital. Detection of liver enzymes was tested to show the effect of co-infection in hepatocytes. ALT was 75.8 U/L which elevated twice than normal, while AST was 92.9U/L, ALP was 94.5U/L and TSB was 1.810mg. Addition to increasing these enzymes, IL-17 also increased.