Background: brucellosis in enzootic bacterial infection of animals and human through infected animals milk, urine, vaginal secretions, uterine products & uncooked infected meat. leads to clinical human infection with brucellosis. Objectives: this study was introduced to look for endemicity, presentation& rate of infection of brucellosis in Anbar Governorate West of Iraq. Materials & methods: one hundred four (104) patients had clinical features of brucellosis investigated serologically, blood cultures. received antibrucella of triple antibiotics for minimum 6 weeks followed up regularly till they cured,  during the period from 30.12.2009 to 30.12.2010. Results: one hundred four (104) cases were diagnosed, fifty four of them (54) were females and fifty (50) were males all of them were adults .Ninety six (96) cases were presented with subacute brucellosis, three (3) cases with knee joint arthritis, (four) 4 cases with sciatic nerve radiculopathy and one case of neurobrucellosis. Conclusion: the study proved that Anbar Governorate is endemic with brucella infection with mild symptoms in most cases and good response with no relapse rate with triple antibrucella antibiotics.