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16642

Screening of some synthetic fused heterocyclic pyrimidines for anti-avian influenza virus (H5N1) activity

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Last updated: 22 Jan 2023

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Abstract

Thirteen chemical compounds belonging to the fused heterocyclic pyrimidines were synthesized and screened in order to assay their antiviral activity against the avian influenza virus (H5N1) A/Chicken/Qalubiya/1/2006(H5N1) by plaque reduction assay on MDCK cells. All tested compounds were non-toxic on the cells. Ten out of thirteen compounds (10, 13, 9, 12, 1, 11, 7, 8, 3 and 4) showed moderate percentage of inhibition respectively at concentration 20 μg/ml while the remaining three compounds (5, 2 and 6) showed weak inhibitory activity respectively at same concentration.

DOI

10.21608/eajbsg.2013.16642

Keywords

Anti, Avian influenza virus, H5N1 – pyrimidine derivatives

Authors

First Name

Omar

Last Name

Alfarouk

MiddleName

R.

Affiliation

- Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt

Email

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City

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Orcid

-

First Name

Ahmed

Last Name

Barakat

MiddleName

B.

Affiliation

- Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt

Email

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City

-

Orcid

-

First Name

Sahar

Last Name

Shoman

MiddleName

A.

Affiliation

Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt

Email

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City

-

Orcid

-

First Name

Husam

Last Name

Ghanem

MiddleName

A.

Affiliation

Department of Microbiology, Faculty of Science, Ain Shams University, Cairo, Egypt

Email

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City

-

Orcid

-

First Name

Mohamed

Last Name

Ali

MiddleName

A.

Affiliation

Department of water pollution, National Research Center, Dokki, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Aymn

Last Name

Rashad

MiddleName

E.

Affiliation

Department of Photochemistry, National Research Center, Dokki,Cairo, Egypt

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City

-

Orcid

-

Volume

5

Article Issue

1

Related Issue

3534

Issue Date

2013-06-01

Receive Date

2018-10-14

Publish Date

2013-06-01

Page Start

25

Page End

33

Print ISSN

2090-0872

Online ISSN

2090-0880

Article File

EAJBSG_Volume 5_Issue 1_Pages 25-33.pdf

PDF . 262.7kB

Link

https://eajbsg.journals.ekb.eg/article_16642.html

Detail API

https://eajbsg.journals.ekb.eg/service?article_code=16642

Order

4

Type

Original Article

Type Code

689

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, G. Microbiology

Publication Link

https://eajbsg.journals.ekb.eg/

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Article

Created At

22 Jan 2023