Aim:  The current research  aims at screening a cohort of  Egyptian pediatric patients after receiving allogenic hemopoietic stem cell transplant (HSCT) in order  to detect prevalence and risk factors of oral chronic graft versus host disease (cGVHD).
Methodology: This study extended for a period of six months and included 47 children who had undergone HSCT at least three months prior to the study at Nasser Institute for Research and Treatment Hospital. The patients were screened for possible oral pathological manifestations. A questionnaire was completed identifying age, sex, type of transplant, conditioning regimen, occurrence of acute GVHD and systemic cGVHD, while unstimulated salivary flow rate and maximum mouth opening were measured.
Results: The results revealed that the number of patients who manifested cGVHD in relation to the whole study population is 32 patients (68.08%). In relation to the whole study population, the number of  patients with oral cGVHD was 26 (55.3%). There was no statistically significant association between appearance of oral cGVHD and most of the investigated risk factors (age ,sex, type of transplant , conditioning, occurrence of acute GVHD P value > 0.05. A significant association was detected between  occurrence of oral cGVHD and systemic cGVHD (mainly skin ) p value < 0.05.
Conclusion: In a sample of Egyptian pediatric patients who underwent HSCT, oral cGVHD is most prevalent among patients with cGVHD  affecting (81.2%) of them. Also the appearance of combined oral  manifestations is common. Appearance of systemic and oral manifestations of cGVHD were significantly associated.