Aim:This study aimed to compare the adhesion of Candida Albicans to the fitting surface of Bre-Flex Versus PEEK removable partial denture bases and mucosa beneath them, , in patients with maxillary class III modified 1 Kennedy's classification
Subjects and methods: Eighteen patients having Kennedy class III modification I Maxillary partially edentulous ridges with fully dentate mandibular arch were divided into two equal groups to fabricate the thermoplastic materials. The first group received Bre.Flex material. The second group received PEEK material. For each studied group, microbiological evaluation was carried-out according to the  follow-up recall visits: at the denture insertion, three weeks and four weeks after denture insertion. The collected data were tabulated and statistically analysed.
Results: showed that the difference between the two groups was statistically significant was reported between two groups regarding microbiological evaluation.
Conclusion: Candida Albicans can grow on both denture base material (Bre-Flex and PEEK). Swabs collected from oral mucosa in Bre-Flex group shows higher number of Candida colonies in comparison to the number of colonies in PEEK group < /p>