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269215

Identification of Candida Species Isolated from Oral Candidiasis in Cancer Patients using PCR-RFLP in Sulaimani, Iraq

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Last updated: 03 Jan 2025

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Abstract

Candida species causes oral candidiasis in immunosuppressed individuals such as cancer patients. This study aimed to determine the rate of candida infections in cancer patients (n= 150) and to identify different species of candida using Polymerase Chain Reaction-restriction fragment polymerase length polymorphism (PCR-RFLP), and to find the effect of candidiasis on the PH of the saliva in cancer patients (n=50) and controls (n=50) (Healthy individuals). The rate of candidiasis was different in patients with different types of cancer.  A higher percentage of oral Candidiasis was observed in carcinoma (54 %), followed by leukemia patients (17.3 %), sarcoma type (15.3%), and lymphoma (13.33%). The highest prevalence of candidiasis was found in the old age group, 40-60years Candida albicans was the most common recorded species,70% in comparison to non- albicans species, followed by other species including: Candida glabrata (12%), Candida kefyr (6.7%), Candida tropicalis (5.3%), Candida krusei (3.3%), and Candida dubliniensis (2.7 %). The pH of saliva was more acidic in cancer patients who have candidiasis in comparison to control individuals (P-value 0.001). In conclusion, this study found that the rate of candidiasis is high among cancer patients and Candida albican is the most common species recorded in cancer patients.

DOI

10.21608/eajbse.2022.269215

Keywords

Oral Candidiasis, Cancer patients, PCR-RFLP, Species of candida

Authors

First Name

Diman

Last Name

Mahmood

MiddleName

M.

Affiliation

Medical Laboratory Department, College of Health and Medical Technology, Sulaimani Polytechnic University, Sulaimani, Iraq.

Email

diman.muhammed.mahmood@spu.edu.iq

City

Iraq

Orcid

-

First Name

Yad

Last Name

Osman

MiddleName

N.

Affiliation

Medical Oncologist, Department of Medical Oncology, Hiwa Cancer Hospital, Sulaimani, Iraq.

Email

-

City

Iraq

Orcid

-

First Name

Sara

Last Name

Nidhamaddin

MiddleName

J.

Affiliation

Medical Oncologist, Department of Medical Oncology, Hiwa Cancer Hospital, Sulaimani, Iraq.

Email

-

City

Iraq

Orcid

-

First Name

Solhan

Last Name

Ahmadissa

MiddleName

M.

Affiliation

Medical Laboratory Department, College of Health and Medical Technology, Sulaimani Polytechnic University, Sulaimani, Iraq.

Email

solhanmustafa98@gmail.com

City

-

Orcid

-

First Name

Alaa

Last Name

Rahim

MiddleName

A.

Affiliation

Medical Laboratory Analysis, Cihan University-Sulaimanya, Slemani, Iraq.

Email

alaaahmadd283@gmail.com

City

Iraq

Orcid

-

First Name

Mariwan

Last Name

Salih

MiddleName

A.

Affiliation

Medical Laboratory Department, College of Health and Medical Technology, Sulaimani Polytechnic University, Sulaimani, Iraq - Medical Laboratory Analysis, Cihan University-Sulaimanya, Slemani, Iraq.

Email

mariwan.abdulla@spu.edu.iq

City

-

Orcid

-

First Name

Taib

Last Name

Hamasoor

MiddleName

A.

Affiliation

Medical Laboratory Department, College of Health and Medical Technology, Sulaimani Polytechnic University, Sulaimani, Iraq. - Medical Laboratory Analysis, Cihan University-Sulaimanya, Slemani, Iraq.

Email

-

City

Iraq

Orcid

-

Volume

14

Article Issue

2

Related Issue

35558

Issue Date

2022-12-01

Receive Date

2022-09-03

Publish Date

2022-11-09

Page Start

115

Page End

126

Print ISSN

2090-0783

Online ISSN

2090-0856

Article File

EAJBSE_Volume 14_Issue 2_Pages 115-126.pdf

PDF . 668.0kB

Link

https://eajbse.journals.ekb.eg/article_269215.html

Detail API

https://eajbse.journals.ekb.eg/service?article_code=269215

Order

269,215

Type

Original Article

Type Code

687

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, E. Medical Entomology & Parasitology

Publication Link

https://eajbse.journals.ekb.eg/

MainTitle

Identification of Candida Species Isolated from Oral Candidiasis in Cancer Patients using PCR-RFLP in Sulaimani, Iraq

Details

Type

Article

Created At

22 Jan 2023