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231586

The Possible Involvement of Protozoans in Causing Cancer in Human

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Last updated: 22 Jan 2023

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Abstract

In the past few years, it has already been proved that the microbial origin of cancer exists and these oncogenic microbes are infectious in nature. After bacteria and viruses, protozoans have also been found to cause cancer in humans and animals. They are eukaryotic, unicellular, anthropozoonotic microorganisms causing several life-threatening diseases and cancer in humans. While aplethora of goodpieces of information was gathered while documenting the role of several protozoans causing cancer in humans, only Plasmodium falciparum has been categorized by the IARC as Group 2A carcinogen. However, certain other protozoan parasites have also got their ability to cause cancer in humans via the integration of protozoan DNA sequences in the host cells. Protozoans cause the stimulation of cell division and proliferation of the host cells by the release of reactive oxygen and nitrogen radicals, DNA damage and the p53 gene inhibition. The present review discusses some cancer-causing protozoan parasites like Leishmania donovani, Trypanosoma brucie, Toxoplasma gondii, Trichomonas vaginalis, Blastocystis hominis, Theileria microti and Cryptosporidium parvum including Plasmodium falciparum in the light of recent researches done so far in the field of microbial origin of cancer. 

DOI

10.21608/eajbse.2022.231586

Keywords

Protozoans, Cancer in Human, Burkitt’s Lymphoma, Hodgkin Lymphoma, Brain and Breast Cancer, gastrointestinal cancer

Authors

First Name

Mohammad

Last Name

Salim

MiddleName

-

Affiliation

S.G.S. Govt P.G. Autonomous College, Sidhi (M.P)

Email

msaleem195195@gmail.com

City

Sidhi

Orcid

0000-0001-7061-8701

First Name

Masroor,

Last Name

Mohammad Shahid

MiddleName

-

Affiliation

People's College of Dental Sciences & Research Center, People's University, Bhopal (M.P.), India

Email

mmsid.824@gmail.com

City

BHOAPL

Orcid

-

First Name

Parween,

Last Name

Shagufta

MiddleName

-

Affiliation

Department of Human Anatomy, All India Institute of Medical Sciences (AIIMS), Bhopal (M.P.) India.

Email

shaggwl88@gmail.com

City

Bhopal

Orcid

-

Volume

14

Article Issue

1

Related Issue

31171

Issue Date

2022-06-01

Receive Date

2022-03-01

Publish Date

2022-04-18

Page Start

71

Page End

86

Print ISSN

2090-0783

Online ISSN

2090-0856

Article File

EAJBSE_Volume 14_Issue 1_Pages 71-86.pdf

PDF . 499.4kB

Link

https://eajbse.journals.ekb.eg/article_231586.html

Detail API

https://eajbse.journals.ekb.eg/service?article_code=231586

Order

7

Type

Original Article

Type Code

687

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, E. Medical Entomology & Parasitology

Publication Link

https://eajbse.journals.ekb.eg/

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Article

Created At

22 Jan 2023