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227953

Re-Evaluating The Role of Demodex Mite in Skin Bio-Balance and

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Last updated: 03 Jan 2025

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Abstract

Demodex mites are obligate human ectoparasites that live in or near pilosebaceous units. D. folliculorum ingests skin cells and sebum, whereas D. brevis burrows deeper into the sebaceous glands and ducts, feeding on gland cells. They may even provide a mutualistic host advantage by feeding on bacteria or other organisms in the follicular canal to keep the dermal bio-balance in check. Demodicosis is the umbrella term for all skin disorders related to Demodex mites. It is still unclear whether Demodex is the underlying cause or the result of pre-existing conditions such as rosacea and other dermatological diseases. Given that, Demodex is not the only cutaneous microbiota involved in these conditions. This review aims to re-evaluate the pathogenicity of the Demodex mite, with a focus on systematic internal causes that may drive pathogenicity, such as immunological imbalance, microbiome alterations, or concomitant infections. Clinical suspicion of the underlying causes of Demodex pathogenicity in various dermatoses can thus aid in early diagnosis and appropriate, timely, and cost-effective treatment.

DOI

10.21608/eajbse.2022.227953

Keywords

demodex, Pilosebaceous units, Microbiome, Rosacea, immunological imbalance

Authors

First Name

Mona

Last Name

El-Sherbini

MiddleName

S.

Affiliation

Medical Parasitology Department, Faculty of Medicine, Cairo university

Email

monas.elsherbini@kasralainy.edu.eg

City

-

Orcid

-

First Name

Nardeen

Last Name

Bocktor

MiddleName

Z.

Affiliation

Medical Parasitology Department, Faculty of Medicine, Cairo university

Email

-

City

-

Orcid

-

First Name

Ashaimaa

Last Name

Hamed

MiddleName

M. R.

Affiliation

Medical Parasitology Department, Faculty of Medicine, Cairo university

Email

-

City

-

Orcid

-

Volume

14

Article Issue

1

Related Issue

31171

Issue Date

2022-06-01

Receive Date

2022-02-25

Publish Date

2022-03-29

Page Start

51

Page End

62

Print ISSN

2090-0783

Online ISSN

2090-0856

Article File

EAJBSE_Volume 14_Issue 1_Pages 51-62.pdf

PDF . 467.2kB

Link

https://eajbse.journals.ekb.eg/article_227953.html

Detail API

https://eajbse.journals.ekb.eg/service?article_code=227953

Order

5

Type

Original Article

Type Code

687

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, E. Medical Entomology & Parasitology

Publication Link

https://eajbse.journals.ekb.eg/

MainTitle

Re-Evaluating The Role of Demodex Mite in Skin Bio-Balance and

Details

Type

Article

Created At

22 Jan 2023