Introduction: Pregnancy and childbirth are very important in every woman's life. Childbirth causes severe pain in the individual and has many adverse effects on the physiologic status of the mother and the fetus and the process of childbirth. Different studies have been done to relieve childbirth pain. Therefore, the present study was conducted with the purpose of systematic review of studies to reduce pain and progress of childbirth in Iran. Materials and Methods: In this systematic review of information from the databases of the Clinical Trials Registration Center, Iranmedex, Magiran, Irandoc, Google scholar, SID, and Iranian articles published in foreign magazines of Pubmed, Proquest, Scopus, Science-Direct databases, with Keywords including pain, childbirth, were searched until December 2016. Studies that met the entrance criteria were studied and criticized. Results: Finally, 72 clinical trials were evaluated. Studies have shown that in order to reduce the pain and progress of childbirth, several methods such as medicinal plants (lavender, cloves, etc.), chemical drugs (pethidine, hyoscine, etc.), and non-medical methods (Thermal Therapy,etc). Among all interventions, in the group of herbal treatments, lavender, and among the chemical drugs Entonox gas reduced the severity of pain and the progress of childbirth. In the field of non-pharmacological methods, acupressure had the greatest impact. Conclusion: Therapeutic methods to reduce the severity of childbirth pain and its progress in Iran are very diverse and among these methods lavender, Entonox gas and acupressure were the most effective treatments. Judging by the definitive effectiveness of all these interventions requires more extensive research with higher sample sizes.