Carbon tetrachloride (CCl₄) is a xenobiotic chemical that eventually is used as an experimental model for investigating the ameliorative activity of medicinal plants. Plantago ovata husk is rich in bioactive antioxidant compounds and different metabolites such as polyphenols, fatty acids, amino acids, and flavonoids therefore, Plantago ovata husk can be used for the treatment of liver diseases. A total of thirty white Albino rats were used, at a weight of about (144-176 g).  Rats were divided into five groups (6 rats/group): (Control group) received nothing. (Oil-treated group) was given olive oil. (CCl₄-treated group) was given CCl₄. (PS-CCl4 treated group) was given daily PSH for six weeks and CCl₄ for 4 weeks. (CCl₄-PStreated group) was given CCl₄ and then given daily PSH. All Groups were anaesthetized and sacrificed. White blood cells (WBCs), Red blood cell count (RBCs), Hematocrit (HCT) and Hemoglobin (Hb) concentration were determined.  Alanine Aminotransferase (ALT) and Aspartate Aminotransferase (ALT) level, bilirubin and total protein were estimated as well as glycogen content in the liver. The CCl₄ induced a significant reduction in red blood cell count, hematocrit and hemoglobin concentration than control and a significant increase in white blood cells. Moreover, liver enzymes, bilirubin and total protein were significantly increased in the CCl₄-treated group than in the control. In general, the Treatment of rats with Psyllium husk powder induced a marked degree of improvement in hematological parameters and a marked increase in glycogen content. Moreover, serum levels of ALT, AST, bilirubin, and total protein were decreased.
               The present study aimed to investigate the possible protective and therapeutic effect of Psyllium husk (PSH) on Carbon Tetrachloride (CCl₄) induced toxicity in albino male rats.