The present study investigated the possible ameliorative effect of Beta-MOS^®on lead-induced toxicity in Nile tilapia. A total of ninety O. niloticus (34.43 ± 0.31 g and 7 weeks age) were used in this study. Fish of mixed sex were divided into 4 groups. The first group which served as control received a basal diet (0% Beta-MOS^®). The second group received a diet supplemented with 0.3% Beta-MOS^®. The third group was exposed to 10 mg Pb acetate L^-1 in water and received a basal diet. The fourth group was exposed to the same dose of Pb acetate (10 mg L^-1) in water and given 0.3% Beta-MOS^®. Initial and final weight as well as weight gain were recorded. Red blood cell count and hemoglobin concentration were determined. Creatinine plasma level was estimated as well as histopathological changes in the kidney. The lead acetate induced a significant reduction in final body weight, weight gain, red blood cell count and hemoglobin concentration than control. Moreover, creatinine was significantly increased in the lead group than control, with retrogressive changes in histopathological sections. Dietary Beta-MOS^® ameliorated all the lead-induced perturbations in the tested parameters.  Dietary Beta-MOS^® ameliorated lead acetate toxicity in Nile tilapia.