Among different types of cancers, hepatocellular carcinoma (HCC) is widely distributed and considered to be the fifth leading cause of death around the world. Although the presence of different treatment choices with liver transplantation and liver excision is at the top of the list, there is a high need for more investigations to be done to figure out variant options with higher efficacy and lower cost. Inflammation and oxidative stress are very common factors in cancer biology that play a substantial role in cancer development and progression. These deep understandings resulted in exploring the branch of phytochemistry to help find effective natural products and their derivatives. Among hundreds of phytochemical choices, gingerol is known for its powerful antioxidant and anti-inflammatory activities positioning it to be a very promising compound added to the list of cancer treatment options. Besides these activities, gingerol was documented to have anti-cancer effects as it arrests the cell cycle as well as induces apoptosis. In our study design, the therapeutic potential of gingerol was evaluated in an animal model. The conclusion that confirms our hypothesis is hoped to have a distinct role in developing cancer therapies.