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234198

Protective Effects of Apricot Oil Against Mercuric Chloride-Induced Hepato-Renal Toxicity in Rats

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Last updated: 22 Jan 2023

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Abstract

This study was designed to investigate the possible protective role of apricot oil against liver and renal toxicity induced by mercuric chloride in rats by using biochemical approaches and tissue analysis. Twenty-four adult male albinos Wistar rats were randomly divided into four groups, the first served as a control; whereas the remaining groups were respectively treated with:  mercuric chloride (0.25 mg/kg body weight i.p) + apricot oil (5ml/ kg b.w; by gavage after one month); apricot oil (5ml/ kg b.w; by gavage) and combination of apricot oil and HgCl2 at the same time. The result showed a moderately decreased body weight in all treated groups compared with the control (p = 0,017). Exposure of rats to mercuric chloride caused a significantly decreased activity of AST, ALT compared with the control, the differences were statistically significant for the AST (P=0,017) and ALT (P=0,027). Supplementation of apricot oil resulted in a decreased level of AST antioxidant enzymes level in the liver. Pancreatic hypoglycemia was noted in the group treated with mercuric chloride plus apricot oil compared to the control. Apricot oil also produced substantial decreases in the concentrations of total cholesterol, urea and creatinine (P<0,05). A significant decrease in phosphorus levels in the mercuric chloride group compared to control was observed. Supplementation of apricot oil resulted in a decrease in protide levels. The results clearly demonstrate that apricot oil treatment augments the antioxidants defense mechanism in mercuric chloride-induced toxicity and provides evidence that it may have a therapeutic role in free radical-mediated diseases.

DOI

10.21608/eajbsd.2022.234198

Keywords

mercury chloride, Apricot oil, antioxidant, Health, Wistar rats

Authors

First Name

Bensaid

Last Name

Ilias

MiddleName

-

Affiliation

Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria

Email

-

City

-

Orcid

-

First Name

Bouazza

Last Name

Sofiane

MiddleName

-

Affiliation

Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria

Email

-

City

-

Orcid

-

First Name

Maï

Last Name

Hicham

MiddleName

-

Affiliation

Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria

Email

-

City

-

Orcid

-

First Name

Djebbar

Last Name

Abdel El Hamid

MiddleName

Ahmed

Affiliation

Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria

Email

-

City

-

Orcid

-

First Name

Benguerrache

Last Name

Djamel

MiddleName

-

Affiliation

Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria

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-

City

-

Orcid

-

First Name

Rebbah

Last Name

Kheira

MiddleName

-

Affiliation

Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria

Email

-

City

-

Orcid

-

First Name

Bekhadda

Last Name

Hadjer

MiddleName

-

Affiliation

Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria

Email

-

City

-

Orcid

-

First Name

Brikhou

Last Name

Slimane

MiddleName

-

Affiliation

Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria

Email

-

City

-

Orcid

-

First Name

Demmouche

Last Name

Abbassia

MiddleName

-

Affiliation

Biotoxicology laboratory. Department of Biology, Faculty of Natural Sciences and life-Djillali Liabes University of Sidi Bel Abbes, Algeria

Email

demmoucheabbassia@yahoo.fr

City

SBA

Orcid

0000-0003-0811-7820

Volume

14

Article Issue

1

Related Issue

30210

Issue Date

2022-06-01

Receive Date

2022-03-23

Publish Date

2022-06-01

Page Start

137

Page End

147

Print ISSN

2090-0775

Online ISSN

2090-0848

Article File

EAJBSD_Volume 14_Issue 1_Pages 137-147.pdf

PDF . 1.1MB

Link

https://eajbsd.journals.ekb.eg/article_234198.html

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https://eajbsd.journals.ekb.eg/service?article_code=234198

Order

9

Type

Original Article

Type Code

685

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry

Publication Link

https://eajbsd.journals.ekb.eg/

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Article

Created At

22 Jan 2023