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196336

Amygdalin Enhances the Antitumor Effect of Sorafenib

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Last updated: 22 Jan 2023

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Abstract

Sorafenib (SOR) is a potent chemotherapeutic agent used for cancer treatment, however, it has several side effects upon administration on some vital organs. Amygdalin (AMY) is a vitamin B-17 that showed several biological activities as an antioxidant, anti-inflammatory, and anticancer agent. This study was conducted to evaluate the effect of the treatment with a combination of SOR/AMY in Ehrlich ascites carcinoma (EAC)-bearing mice. Twenty-four female CD-1 mice were divided into four groups (n=6) as follows: Group 1 (Gp1) was inoculated with 2 × 106 EAC-cells/mouse and served as a positive control. Gp2, 3, and 4 were inoculated with the same number of EAC-cells as in Gp1, and then injected with AMY (50 mg/Kg/14 days), SOR (10 mg/Kg/14 days), and AMY/SOR intraperitoneal (i.p.), respectively. Bodyweight changes, hematological changes, and antitumor indices were evaluated post-treatments. The results showed that AMY had a slight antitumor effect against EAC-bearing mice. Compared to EAC-bearing mice treated with SOR alone, EAC-bearing mice treated with AMY/SOR showed a decrease in the final body weight, tumor volumes, tumor cells count, totally live and dead tumor cells. Furthermore, treatment with AMY/SOR ameliorated the hematological changes. In summary, co-treatment with AMY enhanced SOR antitumor efficacy in EAC-bearing mice. 

DOI

10.21608/eajbsd.2021.196336

Keywords

antitumor, Amygdalin, Sorafenib, EAC-bearing mice

Authors

First Name

Alaa

Last Name

Elmetwalli

MiddleName

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Affiliation

Department of Clinical Trial Research Unit and Drug Discovery, Egyptian Liver Research Institute and Hospital (ELRIAH), Mansoura, Egypt

Email

dr.prof2011@gmail.com

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Orcid

-

First Name

Aya

Last Name

Abdel Khalek

MiddleName

M.

Affiliation

Biochemistry Section, Chemistry Department, Faculty of Science, Tanta University, Egypt

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-

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Orcid

-

First Name

Sabry

Last Name

El-Naggar

MiddleName

A.

Affiliation

Zoology Department, Faculty of Science, Tanta University, Egypt

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-

City

-

Orcid

-

First Name

Mohammed

Last Name

El-Magd

MiddleName

A.

Affiliation

Anatomy and Embryology Department, Faculty of Veterinary Medicine, Kafrelsheikh University, Egypt

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-

City

-

Orcid

-

First Name

Afrah

Last Name

Salama

MiddleName

F.

Affiliation

Biochemistry Section, Chemistry Department, Faculty of Science, Tanta University, Egypt

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-

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-

Orcid

-

Volume

13

Article Issue

2

Related Issue

26416

Issue Date

2021-12-01

Receive Date

2021-07-29

Publish Date

2021-12-01

Page Start

61

Page End

68

Print ISSN

2090-0775

Online ISSN

2090-0848

Article File

EAJBSD_Volume 13_Issue 2_Pages 61-68.pdf

PDF . 744.0kB

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https://eajbsd.journals.ekb.eg/article_196336.html

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https://eajbsd.journals.ekb.eg/service?article_code=196336

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Original Article

Type Code

685

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry

Publication Link

https://eajbsd.journals.ekb.eg/

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Article

Created At

22 Jan 2023