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164581

Protective Effects of Vitamin C on Ivermectin Induced Toxicity on Kidney Functions and Brain Tissue in Rabbits (Oryctolagus cuniculus

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Last updated: 22 Jan 2023

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Abstract

The aim of this study was to evaluate the effects of repeated intake of a high dose of Ivermectin (IVM) alone or with co-administration of Vitamin C on kidney biochemical parameters and histological structure of kidney and brain of male rabbits (Oryctolagus cuniculus). Male rabbits were distributed into four groups (5 rabbits/group) and treated for three consecutive weeks: receiving distilled water; IVM 2 mg/kg b.w. subcutaneously, 3 times a week; IVM + Vitamin C 20 mg/1mL by gavage and IVM + Vitamin C 200mg /kg of diet in food. IVM significantly (p < 0.05) increased the plasma level of creatinine compared to the control group. Co-treatment with vitamin C orally by gavage ameliorated this level compared to IVM group. The histopathological examination of kidney sections in IVM alone treated group showed dilated Bowmans' spaces, dilated renal tubules, vascular congestion and cell infiltration. The brain tissues demonstrated vacuolated neuropil and degenerative changes in nerve cells in both the cerebral cortex and hippocampus of IVM-treated rabbits. However, these histological changes were moderate in both vitamin C co-treated groups. In conclusion, vitamin C has a protective effect against nephrotoxicity and neurotoxicity induced by subacute administration of a high dose of IVM.

DOI

10.21608/eajbsd.2021.164581

Keywords

Ivermectin, vitamin c, biochemical parameters, histopathology, Rabbit

Authors

First Name

Makhlouf

Last Name

Chahrazed

MiddleName

-

Affiliation

-Department of Biology, Faculty of Nature and Life Sciences, University Blida 1, BP 270. Soumaa, Blida, Algeria - Natural Resources Laboratory, University Mouloud Mammeri, BP 15017. Tizi-Ouzou, Algeria

Email

chahrazedmakhlouf@yahoo.com

City

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Orcid

-

First Name

Khaldoun

Last Name

Hassina

MiddleName

Oularbi

Affiliation

-Department of Biology, Faculty of Nature and Life Sciences, University Blida 1, BP 270. Soumaa, Blida, Algeria - Natural Resources Laboratory, University Mouloud Mammeri, BP 15017. Tizi-Ouzou, Algeria

Email

khaldounhassina@hotmail.fr

City

-

Orcid

-

First Name

Bokreta

Last Name

Soumya

MiddleName

-

Affiliation

-Department of Biology, Faculty of Nature and Life Sciences, University Blida 1, BP 270. Soumaa, Blida, Algeria - Natural Resources Laboratory, University Mouloud Mammeri, BP 15017. Tizi-Ouzou, Algeria

Email

-

City

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Orcid

-

First Name

Oularbi

Last Name

Yasmine

MiddleName

-

Affiliation

National Higher School of Agronomy, El-Harrach, 16200, Algiers, Algeria

Email

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City

-

Orcid

-

First Name

Zerrouke

Last Name

Houda

MiddleName

-

Affiliation

Department of Biology, Faculty of Nature and Life Sciences, University Blida 1, BP 270. Soumaa, Blida, Algeria

Email

-

City

-

Orcid

-

First Name

Daoudi

Last Name

Nacira

MiddleName

Zerrouki

Affiliation

Natural Resources Laboratory, University Mouloud Mammeri, BP 15017. Tizi-Ouzou, Algeria

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-

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-

Orcid

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Volume

13

Article Issue

1

Related Issue

21528

Issue Date

2021-06-01

Receive Date

2021-02-28

Publish Date

2021-04-17

Page Start

63

Page End

77

Print ISSN

2090-0775

Online ISSN

2090-0848

Article File

EAJBSD_Volume 13_Issue 1_Pages 63-77.pdf

PDF . 974.9kB

Link

https://eajbsd.journals.ekb.eg/article_164581.html

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https://eajbsd.journals.ekb.eg/service?article_code=164581

Order

5

Type

Original Article

Type Code

685

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry

Publication Link

https://eajbsd.journals.ekb.eg/

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Article

Created At

22 Jan 2023