This study was carried out to investigate the ameliorative effect of L-carnitine on monosodium glutamate (MSG)-induced testicular toxicity in male mice. Sixty adult male mice were randomized into 6 groups (n = 10). In addition, to the control male mice group (Gp1) that orally administered distilled water, Gp2 mice received 150 mg/kg/day L-carnitine for 35 days. Monosodium glutamate (MSG) was orally administered to male mice at doses of 0.3 and 0.6 mg/g body weight individually (Gp3 & Gp4) and in combination with 150 mg/kg body weight of L-carnitine for 35 days (Gp5 & Gp6). The morphometric parameters, histopathological findings and immunohistochemical studies for PCNA, Ki-67 and Claudin-1 of the testis tissue demonstrated that L-carnitineattenuated and ameliorated the alterations in testicular tissues caused by MSG exposure.
Conclusions: The findings of the present study indicated that treatment of male mice with L-carnitine banned MSG-induced testicular toxicity by improving testicular structure status.