Nowadays, tumors are recorded a high percentage among human beings due to exposure to different carcinogens. DMBA and mouse will be established models for study tumorigeneses.  A trial was done to suppress cell proliferation using Lagenaria siceraria (LS). Mice were divided into C: control animals received a single injection of corn oil and a daily dose of distilled water, D: animals received a single dose of DMBA and 91 days ago, mice received morning and night daily oral dose of distilled water for 30 days, and DL: Animals received a single dose of DMBA (10 mg/ 100 g b.w.) and 91 days ago, mice received morning and night daily oral dose of LS (100 mg/ Mouse) for 30 days. Our results showed a single dose of DMBA (10 mg/ 100 g b.w.) has a stimulatory effect on the cellular activity, DNA synthesis, and cell proliferation of epithelial cells in the ileum, however, LS mostly treated this effect. BAX and BCL2 immunohistochemistry revealed DMBA induced excessive cell proliferation and hyperplasia (dysplasia), while LS almost treated this effect of DMBA. These results suggest LS modulates the toxic effect induced by DMBA in the ileum. A promising data for cancer herbal therapy in human beings.