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78773

Mitigations of Syzygium cummini Fruit Extract on CdCl2 Induced Histopathological Changes in Laboratory Mouse Epididymids

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Last updated: 03 Jan 2025

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Abstract

The aim of present project was to determine the harmful effects of CdCl2 on epididymis of adult mice (Mus musculus). Histopathological changes in epididymis of mice treated with 50ppm of CdCl2 were studied in this research work. Moreover, remedial effects of Jambul fruit extract were also studied. Study was conducted on 30 male albino mice divided into three groups (n=10) as follows; {(a) Control (C); (untreated); (b) CdCl2 {50ppm CdCl2 as drinking water (15 days) and for natural recovery CdCl2 free water (7days); (c) CdCl2+Jambul extract (CdCl2+J) 50ppm CdCl2 in drinking water for 15 days followed by 0.2mLJambul extract (7days)}. All animals were dissected on day 21st for surgical removal of epididymis. The results revealed that mean tubular cross-sectional area of caput, corpus and cauda epididymis was significantly increased in CdCl2 treated group compared to Control and Cd+J treated groups. A single peritoneal administration of soluble cadmium causes an acute hemorrhagic reaction in proximal end of caput epididymis. The lining epithelium of the proximal caput was atrophied, tubules were dilated and spermatozoa within the lumen were disintegrated.

DOI

10.21608/eajbsd.2020.78773

Keywords

CdCl2, epididymis, histopathology, Syzygium cummini, Mice

Authors

First Name

Iram

Last Name

nayat

MiddleName

-

Affiliation

Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan

Email

-

City

-

Orcid

-

First Name

Syeda

Last Name

Ahmad

MiddleName

Nadia

Affiliation

Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan

Email

-

City

-

Orcid

-

First Name

Hafsa

Last Name

Batool

MiddleName

-

Affiliation

Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan

Email

-

City

-

Orcid

-

First Name

Asma

Last Name

Younis

MiddleName

-

Affiliation

Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan

Email

-

City

-

Orcid

-

First Name

Tahir

Last Name

Abbas

MiddleName

-

Affiliation

Department of Biology Government college Sillanwali, District Sargodha, Pakistan

Email

-

City

-

Orcid

-

First Name

Sajida

Last Name

Batool

MiddleName

-

Affiliation

Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan

Email

-

City

-

Orcid

-

First Name

Muhammad

Last Name

Kanwal

MiddleName

Ali

Affiliation

Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan

Email

-

City

-

Orcid

-

First Name

Khawaja

Last Name

Ahmad

MiddleName

Raees

Affiliation

Department of Zoology, University of Sargodha, Sargodha, Punjab, Pakistan

Email

raees.ahmad@uos.edu.pk

City

-

Orcid

-

Volume

12

Article Issue

1

Related Issue

10468

Issue Date

2020-06-01

Receive Date

2020-02-13

Publish Date

2020-06-01

Page Start

49

Page End

58

Print ISSN

2090-0775

Online ISSN

2090-0848

Article File

EAJBSD_Volume 12_Issue 1_Pages 49-58.pdf

PDF . 760.3kB

Link

https://eajbsd.journals.ekb.eg/article_78773.html

Detail API

https://eajbsd.journals.ekb.eg/service?article_code=78773

Order

6

Type

Original Article

Type Code

685

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry

Publication Link

https://eajbsd.journals.ekb.eg/

MainTitle

Mitigations of Syzygium cummini Fruit Extract on CdCl2 Induced Histopathological Changes in Laboratory Mouse Epididymids

Details

Type

Article

Created At

22 Jan 2023