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69041

Adipocyte of Obese Breast Cancer Patients Is Characterized by The Overexpression of Caveolin-1 Protein/Mediator the Main Constituent of the Plasma Membrane Vesicles Caveolae That

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Last updated: 03 Jan 2025

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Abstract

Breast cancer (BC) is the second leading mortality cause due to poor survival rates compared to lung cancer all over the world.  Recently, lifestyle increased obesity among the population globally. Since, the adipose tissues (AT) are the major contributor to the volume of the breast and adipocytes cells, which constitute AT are one of the major prominent cells play an effective role in cancer progression via releasing different mediators and adipokines. Thus, AT may display a crucial role in BC progression, especially in obese patients compared to non-obese patients, which characterized by increased AT.  Interestingly, adipocytes are characterized by expressing caveolin-1 (Cav-1) protein. Cav-1 constitutes the lipid raft of caveola which contains different proteolytic enzymes inducing cancer metastasis. In this regard, the aim of the present study was to explore the level of expression of Cav-1 protein in the tissue specimen of 5 non-obese vs. 15 obese patients using immunohistochemistry (IHC) and immunoblotting techniques. Our finding demonstrates that thelevel ofCav-1expression was statistically significantly low in non-obese compared to obese BC patients (p < 0.05). Herein, our results revealed that the highest expression of Cav-1in obese patients compared to non-obese (control) patients can be considered as a biomarker for BC patients.

DOI

10.21608/eajbsd.2020.69041

Keywords

breast cancer, adipose tissues

Authors

First Name

Aya

Last Name

Saber

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt

Email

-

City

-

Orcid

-

First Name

Sherif

Last Name

Ibrahim

MiddleName

Abdelaziz

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Hosney

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt

Email

mhosney@sci.cu.edu.eg

City

-

Orcid

0000-0002-1979-4125

First Name

Hossam

Last Name

Mohamed

MiddleName

Taha

Affiliation

1-Department of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt. 2-Faculty of Biotechnology, October University for Modern Sciences and Arts, Giza

Email

hotaha@msa.eun.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

Fares

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Al-Azhar University, Cairo

Email

moh.fares@azhar.edu.eg

City

-

Orcid

-

First Name

Salwa

Last Name

Sabet

MiddleName

-

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt

Email

salwa@sci.cu.edu.eg

City

-

Orcid

-

First Name

Mohamed

Last Name

El-Shinawi

MiddleName

-

Affiliation

Department of General Surgery, Faculty of Medicine, Ain Shams University, Cairo, 11566, Egypt

Email

mohamedshinawi@med.asu.edu.eg

City

-

Orcid

-

First Name

Mona

Last Name

Mohamed

MiddleName

Mostafa

Affiliation

Department of Zoology, Faculty of Science, Cairo University, Giza, 12613, Egypt

Email

mmostafa@sci.cu.edu.eg

City

-

Orcid

-

Volume

12

Article Issue

1

Related Issue

10468

Issue Date

2020-06-01

Receive Date

2019-12-25

Publish Date

2020-06-01

Page Start

1

Page End

13

Print ISSN

2090-0775

Online ISSN

2090-0848

Article File

EAJBSD_Volume 12_Issue 1_Pages 1-13.pdf

PDF . 650.1kB

Link

https://eajbsd.journals.ekb.eg/article_69041.html

Detail API

https://eajbsd.journals.ekb.eg/service?article_code=69041

Order

1

Type

Original Article

Type Code

685

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry

Publication Link

https://eajbsd.journals.ekb.eg/

MainTitle

Adipocyte of Obese Breast Cancer Patients Is Characterized by The Overexpression of Caveolin-1 Protein/Mediator the Main Constituent of the Plasma Membrane Vesicles Caveolae That Contain Proteins Contribute to Breast Cancer Progression

Details

Type

Article

Created At

22 Jan 2023