Background: The ability of women to reproduce is well known to decline with age. Advanced maternal age is related to reduce fertility and adverse pregnancy outcomes. There is evident decline in human fertility with age due to several histological changes occur with progressive age.
Objective: The research was intended to know that some cellular modifications happen during the reproductive and post-menopause phases in human endometrial cells.
Materials and methods: 30 womb samples each from reproductive and postmenopausal women were collected from unembalmed human cadavers. Before being taken to electron microscopy, samples were resolved in glutaraldehyde solution and osmium tetroxide as fixative.  Small sizes of endometrial specimens were drawn into a unique fixative (i.e., 5% glutaraldehyde in a buffer of 0.1μphosphate (PH 7.4), then washed three times in a buffer solution. The moved to prepare thin sections for electron microscopy.  Samples were integrated at 60cº for two days in Arledit –Rezen capsule. Thin parts for E.M. were then ready study Ultra-structural cell of endometrium
 Results: Many differences were clear and evident when comparison was made between reproductive and postmenopause stages of endometrial cell ultrastructurally. The structural changes involved shape, density, cell organelles aggregation in general, and were assigned to age, as well as degeneration, deposition, and irregularity.
 Conclusion: Present work results indicated that, increase the amount of cell organelles in uterine cells of young women, while the old ages characterize by less number of organelles and degenerated.