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Effect of Moringa Leaves Extract on Some Metabolic and Biochemical Alterations in Induced Type 2 Diabetes Male Albino Rats.

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Last updated: 03 Jan 2025

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Abstract

Type 2 diabetes is associated with bad health consequences. The current study focused on the effect of Moringa olifera (MO) extract on some metabolic and biochemical parameters in induced type 2 diabetic albino rats. Twenty-eight albino male rats were selected and randomly divided into 4 groups. The control rats fed on a standard balanced diet and the second group fed standard balanced diet and gavaged with MO extract 50 mg/kg b.wt. The third group was a diabetic group that was induced to type 2 diabetes by high dietary fat for 8 weeks followed by streptozotocin (STZ) 25 mg/kg intraperitoneal (i.p.) while the fourth group was induced to type 2 diabetes and gavaged with MO extract 50 mg/kg b.wt. Treatment was continued for 4 weeks and, final body weight was recorded. Serum Lipid Profile, insulin resistance, super oxide dismutase (SOD), tumor necrosis factor alpha (TNF-α), resistin and liver enzymes were determined. Histopathology to hepatic tissue was also done. Results revealed a significant reduction in final body weights of diabetic rats than control. Serum lipid profile was deteriorated in the diabetic group. Insulin resistance, TNF-α, resistin and liver enzymes were significantly upregulated (P<0.05) in the diabetic rats than control while SOD was significantly reduced (P<0.05). Liver histopathology showed diffuse hazy vacuolation with leukocytic infiltration in the diabetic group and estrogen receptor (ER) immunostaining was significantly declined in diabetic group. All these changes were ameliorated with MO extract administration to diabetic rats. MO extract has a potential preventive effect against metabolic and biochemical alterations of type 2 diabetes.

DOI

10.21608/eajbsd.2019.30436

Keywords

Type 2 Diabetes, moringa extract, rat, Insulin Resistance, TNF-α

Authors

First Name

Dalia

Last Name

Zeidan

MiddleName

W.

Affiliation

Department of Home and Economics, Nutrition and Food Science Branch, Faculty of Education, Suez Canal University, Egypt

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Orcid

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First Name

Mohamed

Last Name

Soliman

MiddleName

T. A.

Affiliation

College of Applied Medical Sciences, Department of Medical Laboratory Sciences, University of Bisha, Bisha 61922, p.o. Box 551, Kingdom of Saudi Arabia

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City

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Orcid

-

First Name

Seham

Last Name

Helmy

MiddleName

A.

Affiliation

-Department of Cytology and Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt. -Department of Nursing, College of Applied Medical Sciences, University of Bisha, Bisha 61922, p.o. Box 551, Kingdom of Saudi Arabia.

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Orcid

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First Name

Hala

Last Name

Ebaid

MiddleName

M.

Affiliation

Department of Zoology, Faculty of Science, Suez Canal University, Ismailia, Egypt

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City

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Orcid

-

First Name

Heba

Last Name

Abdelrazek

MiddleName

M. A.

Affiliation

Department of Physiology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

hebaabdelrazekvet@gmail.com

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Orcid

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Volume

11

Article Issue

1

Related Issue

4840

Issue Date

2019-06-01

Receive Date

2019-01-25

Publish Date

2019-06-01

Page Start

33

Page End

47

Print ISSN

2090-0775

Online ISSN

2090-0848

Article File

EAJBSD_Volume 11_Issue 1_Pages 33-47.pdf

PDF . 1.6MB

Link

https://eajbsd.journals.ekb.eg/article_30436.html

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https://eajbsd.journals.ekb.eg/service?article_code=30436

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Original Article

Type Code

685

Publication Type

Journal

Publication Title

Egyptian Academic Journal of Biological Sciences, D. Histology & Histochemistry

Publication Link

https://eajbsd.journals.ekb.eg/

MainTitle

Effect of Moringa Leaves Extract on Some Metabolic and Biochemical Alterations in Induced Type 2 Diabetes Male Albino Rats.

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Article

Created At

22 Jan 2023