Background:Herbal medicine showed an important role in diabetes and other disorders treatment. Using natural products in animal diabetic models is still unclear so that in this study we aimed to investigate the possible effect of Chamomile extract on the diabetic dysfunctions-induced by streptozotocin (STZ) through the histopathological and immunohistochemical point of view.
Result: Our experiment was carried out on 4 rat groups, five rats in each to study the effect of Chamomile water extract on STZ -induced diabetes .The animals were classified into four groups. A negative control group (G1).  A positive diabetic control group (G2) STZ (45 mg/kg body weight in 0.1 M citrate buffer, pH 4.5) was injected intraperitoneally to rats after all overnight fasting (all animals exhibited hyperglycemia within 36 to 48 hr). Chamomile treatment group (G3) normal rats administered water extract of Chamomile, orally at a dose of 200 mg/kg body weight for 21 successive days. Diabetic-Chamomile treated group (G4) diabetic rats received 1 ml water extract of Chamomile for 21 days 36 h post- STZ injection.
Conclusion: Histopathological investigations of our result of pancreas, kidneys, spleen and liver besides pancreatic anti-insulin and caspase-3 monoclonal antibody marker were carried out, the collected data revealed protective, and enhancement effect of Chamomile against STZ- induced diabetes in rats.