The present study aimed to determine the histological structure, histochemical aspects and ultrastructure of the lingual mucosa of two reptilian species Uromastyx aegyptius and Hemidactylus turcicus (which differ in habitat and feeding) by using light, scanning and transmission electron microscopes. The dorsal surface of the tongue in the two species shows many types of lingual papillae (reticular papillae in U. aegyptius and cylindrical and filamentous papillae in H. turcicus). Microvilli and microridges are widely distributed over the surface of the papillae. In U. aegyptius, the branched alveolar glands and compound tubular glands are found, while the mucous glands appear in H. turcicus. Transmission electron microscope showed that the secretory granules in U. aegyptius have more electron-dense core and small electron-dense peripheral areas, while in H. turcicus a large number of spherical secretory granules have very electron-dense cores and more electron-dense peripheral regions. The tongues of the two species were positive for "periodic acid-Schiff"(PAS), PAS-Alcian blue and bromophenol blue stains with variable degrees of intensities. The main difference in the dorsal lingual mucosal pattern between the present two reptile's lies in some peculiarity of diet as the Uromastyx is herbivourous and the Hemidactylus is insectivorous species.