The possible protective effects of Panax ginseng on testicular damage induced by exposure to formaldehyde were studied. Twenty-four male albino rats were divided into 4 groups (6 rats each). The first group was served as a control. The second group was exposed to 17.6 ppm of 36% formaldehyde with the actual dynamically in an inhalation chamber for 6 hours daily for 30 days. The third group was treated with P. ginseng at a dose of 100 mg/kg body weight only for 30 days. The fourth group was treated with P. ginseng at a dose level of 100 mg/kg before formaldehyde exposure with the same exposure time and days. Testes of the experimental animals were used for biochemical, histopathological and histochemical studies. Results revealed that exposure to formaldehyde alone led to a significant increase in the testicular tissue lipid peroxidation and a significant decrease in the reduced glutathione (GSH) content of the testes and testosterone hormone level. There were changes in blood vessels, exfoliation of spermatogenic cells in some tubules with a decrease in the length of the spermatids and vacuolation of spermatogenic layers, while using P. ginseng prior to formaldehyde exposure led to restoration of the normal structure of most of the seminiferous tubules, an increase in testosterone hormones and GSH levels, and a decrease in the lipid peroxidation. In conclusion, treatment of rats with 100 mg/kg P. ginseng prior exposure to formaldehyde led to a good protection of the testes against the harmful effects induced by formaldehyde vapours.